2006-2007 Undergraduate Calendar

Biotechnology  
Director Heather L. Gordon Participating Faculty Jeffrey K. Atkinson (Chemistry), Michael J. Bidochka (Biological Sciences), Ian D. Brindle (Chemistry), Douglas H. Bruce (Biological Sciences), Robert L. Carlone (Biological Sciences), Alan J. Castle (Biological Sciences), Vincenzo De Luca (Biological Sciences), Charles Després (Biological Sciences), Travis Dudding (Chemistry), Heather Gordon (Chemistry), Yousef Haj-Ahmad (Biological Sciences), Tomas Hudlicky (Chemistry), Fiona Hunter (Biological Sciences), Deborah Inglis (Biological Sciences), Costa Metallinos (Chemistry), Gary Pickering (Biological Sciences), Melanie Pilkington (Chemistry), Andrew Reynolds (Biological Sciences), Adonis Skandalis (Biological Sciences), Gaynor Spencer (Biological Sciences), Edward Sternin (Physics), Jeffrey Stuart (Biological Sciences), Art van der Est (Chemistry), Hongbin (Tony) Yan (Chemistry) Director of Co-operative Programs Cindy Dunne Co-operative Program Co-ordinator J.K. Atkinson  
General Information Go to top of document
Administrative Assistant Chris Skorski 905-688-5550, extension 3406 Mackenzie Chown E206 http://www.brocku.ca/biotechnology/ Biotechnology is the use of living organisms to produce goods and services for practical and industrial purposes. Biotechnology has been used for centuries in fermentation and the making of bread and cheese, but today involves new scientific tools like genetic and protein engineering, cell fusion and production of monoclonal antibodies. Biotechnology is a strategic technology and an important economic component of industrialized nations. Biotechnology at Brock is a joint venture of the departments of Biological Sciences and Chemistry, with courses drawn from both departments plus courses designed specifically for the program. The Biotechnology Co-op program combines academic and work terms over a period of five academic years. Students spend two years in an academic setting studying the fundamentals of Biotechnology prior to their first work placement. Successful completion of courses in the core areas of Biotechnology provides the necessary academic background for the work experience. In addition to the current fees for courses in academic study terms, Biotechnology Co-op students are assessed an administrative fee for each work term (see the Schedule of Fees). Eligibility to continue in the Biotechnology Co-op program is based on the student's major and non-major averages. A student with a minimum 70 percent major average and a minimum 60 percent non-major average may continue. A student with a major average lower than 70 percent will not be permitted to continue in the Biotechnology Co-op program, but may continue in the non-co-op Biotechnology stream. If a student subsequently raises his/her major average to 70 percent, the student may be readmitted only if approved by the Co-op Admissions Committee. For further information, see the Co-op Programs section of the Calendar, and contact the Centre for Biotechnology. The Biotechnology Co-op program designation will be awarded to those students who have honours standing and who have successfully completed a minimum of twelve months of Co-op work experience.  
Program Notes Go to top of document
1.  CHEM 3P40 or 3P41 are strongly recommended as year 3 electives for students who intend to take BTEC 4F90 and 4F91 in the Department of Chemistry in year 4.  
2.  Students who anticipate doing graduate studies in Chemistry should have credit in CHEM 2P12, 2P32, 2P42, 3P21 and 3P40 or 3P41 in addition to the other required courses in CHEM.  
3.  In all 20 credit programs, at least 12 credits must be numbered 2(alpha)00 or above, six of which must be numbered 2(alpha)90 or above and of these, three must be numbered 3(alpha)90 or above. In all 15 credit degree programs, at least seven credits must be numbered 2(alpha)00 or above, three of which must be numbered 2(alpha)90 or above.  
Honours Program Go to top of document
Year 1
- BIOL 1F90
- CHEM 1F92
- MATH 1P01 and 1P02 or MATH 1P97 and 1P98
- PHYS 1P21 or 1P91 (recommended)
- one of PHYS 1P22, 1P23, 1P92, 1P93 (recommended)
- one Humanities context credit or Social Science context credit
Year 2
- BTEC 2P09 and 2P63
- BIOL 2F01
- CHEM 2P20 and 2P21
- one of BIOL 2P05, 2P92, 2P94, 2P96, 2P98 (recommended), 2Q04
- one of CHEM 2P12, 2P32, 2P42
- the Humanities context credit or Social Science credit not taken in year 1
Year 3
- BTEC 3P09 and 3P50
- BTEC 3P62 or 3P63
- BCHM 3P01 and 3P02
- CHEM 3P20
- one credit from BTEC 3P95, BCHM 3P25, BIOL 3P28, 3P43, 3P51, CHEM 3P21, 3P40, 3P41, 3P60
- one elective credit (see program notes 1 and 2)
Year 4
- BTEC 3P62 or 3P63 (not taken in year 3)
- BTEC 4F90 and 4F91 (see program note 1)
- one credit from BTEC 3P95, 4P06, 4P08, 4P09, 4P18, 4P21, 4P57, 4P58, BIOL 4P10, 4P51, 4P53
- one of BTEC 4P27, 4P67, 4P68
- one elective credit (see program note 2)
Biotechnology Co-op (Honours only) Students admitted to the Biotechnology Co-op program must follow an approved program pattern. The most common pattern is listed below. For other approved patterns, consult the Co-op Office. Year 1
- BIOL 1F90
- CHEM 1F92
- MATH 1P01 and 1P02 or MATH 1P97 and 1P98
- PHYS 1P21 or 1P91 (recommended)
- one of PHYS 1P22, 1P23, 1P92, 1P93 (recommended)
- one Humanities context credit or Social Science context credit
Year 2
- BTEC 2P09 and 2P63
- BIOL 2F01
- one of BIOL 2P05, 2P92, 2P94, 2P96, 2P98 (recommended), 2Q04
- one of CHEM 2P12, 2P32, 2P42
- CHEM 2P20 and 2P21
- SCIE 0N90
- the Humanities context credit or Social Science credit not taken in year 1
Spring/Summer Sessions:
- BTEC 0N01
Year 3 Fall Term:
- BTEC 3P09
- BCHM 3P01
- CHEM 3P20
- one credit from BCHM 3P25, BIOL 3P28, 3P51, 3P95, CHEM 3P21, 3P40, 3P60
Winter Term:
- BTEC 0N02
Year 4 Fall Term:
- BTEC 0N03
Winter Term:
- BTEC 3P50
- BTEC 3P62 or 3P63
- BCHM 3P02
- one credit from BTEC 3P43, 3P95, BIOL 3P28, 3P51, CHEM 3P21, 3P41, 3P60
Year 5
- BTEC 3P62 or 3P63 (not taken in year 4)
- BTEC 4F90 and 4F91
- one credit from BTEC 4P06, 4P08, 4P09, 4P18, 4P21, 4P57, 4P58, BIOL 4P51, 4P53
- one of BTEC 4P27, 4P67, 4P68
- one elective credit (see program note 2)
 
Pass Program Go to top of document
Satisfactory completion of the first three years of the Honours program entitles a student to apply for a Pass degree.  
Description of Courses Go to top of document
Note that not all courses are offered in every session. Refer to the applicable term timetable for details. # Indicates a cross listed course * Indicates primary offering of a cross listed course  
Prerequisites and Restrictions Go to top of document
Students must check to ensure that prerequisites are met. Students may be deregistered, at the request of the instructor, from any course for which prerequisites and/or restrictions have not been met. BTEC 2P09 Introduction to Biotechnology Traditional and modern biotechnology. Topics include fermentation processes, medical, agricultural and forensic applications; the use of biotechnology in waste treatment. Lectures, lab, 6 hours per week. Prerequisites: BIOL 1F90 and CHEM 1F92. #BTEC 2P63 Introduction to Biophysical Chemistry (also offered as CHEM 2P63) Physical chemistry as applied to biological sciences. Introductory thermodynamics, kinetics, equilibria and transport phenomena as applied to proteins, biological membranes and other biological systems. Laboratory work includes kinetic measurements, equilibrium constant measurements and protein purification and characterization. Lectures, lab, 6 hours per week. Prerequisites: CHEM 1F92; MATH 1P01 and 1P02 (preferred), or MATH 1P97. BTEC 3P09 Bioreactor Processes Fermentation technology and bioprocessing; the kinetics and thermodynamics of fermentation. Topics include batch and continuous fermentation, biomass production (single-cell proteins), immobilized systems, by-product recovery and scale-up. Lectures, lab, 6 hours per week. Prerequisite: BTEC 2P63. #BTEC 3P43 Applied Microbiology (also offered as BIOL 3P43) Ecology of micro-organisms and special adaptations that permit their use in biotechnology and applied microbiology. Lectures, lab, 6 hours per week. Restriction: open to BTEC, BCHM, BIOL (single or combined), BIOL (Honours)/BEd (Intermediate/Senior), BMED, NEUR and OEVI majors until date specified in registration guide. Students must have a minimum of 8.0 overall credits. Prerequisite: BIOL 2P98 or permission of the instructor. #BTEC 3P50 Molecular Genetics (also offered as BIOL 3P50) Topics include the genetic code and information flow from nucleic acids to proteins, RNA and protein synthesis; prokaryotic and eukaryotic chromosomes; gene organization; transcription, RNA processing; codon usage; enhancer and transposons. Lectures, 3 hours per week; lab, 3 hours per week for 6 weeks. Restriction: open to BTEC, BCHM, BIOL (single or combined), BIOL (Honours)/BEd (Intermediate/Senior), BMED, NEUR and OEVI majors until date specified in registration guide. Students must have a minimum of 8.0 overall credits. Prerequisite: BIOL 2F01 or permission of the instructor. #BTEC 3P62 Bio-organic Chemistry (also offered as CHEM 3P62) Mechanistic description of the biosynthesis and metabolism of natural products including alkaloids, terpenes and acetate-derived compounds. Selected examples of biologically/medicinally active classes of natural products along with their physiological modes of activity. Lectures, lab, 6 hours per week. Prerequisite: CHEM 2P21. #BTEC 3P63 Protein and Nucleic Acid Chemistry (also offered as CHEM 3P63) Structure and chemistry of proteins and nucleic acids. Selected aspects of transcription, translation, protein folding, post-translational modification, targeting, synthesis and sequencing, and detection techniques. Lectures, lab, 6 hours per week. Prerequisite: CHEM 2P21. #BTEC 3P95 Techniques in Biochemistry and Molecular Biology (also offered as BCHM 3P95 and BIOL 3P95) Theory and practice of basic techniques in nucleic acid and protein manipulations and analysis. Lab, 6 hours per week. Restriction: open to BTEC, BCHM, BIOL (single or combined), BIOL (Honours)/BEd (Intermediate/Senior), BMED, NEUR and OEVI majors until date specified in registration guide. Students must have a minimum of 8.0 overall credits. Prerequisite: BIOL 2F01. Note: designed for students interested in biochemistry, molecular biology and molecular ecology. BTEC 4F90 Research Project Experimental research carried out under faculty supervision. Restriction: permission of the Director. BTEC 4F91 Thesis The thesis will incorporate the results of the research project and will form the basis of a seminar presented by the student. Restriction: open to BTEC majors with approval to year 4 (honours). Co-requisite: BTEC 4F90. #BTEC 4P06 Bioinformatics (also offered as BCHM 4P06 and BIOL 4P06) Genome sequencing projects, gene discovery and gene expression. DNA/RNA/Protein sequence data, including mutagenic processes, molecular evolution and systematics, codon usage, reconstruction of ancient molecules, and prediction of higher-level molecular structure. Lectures, seminar, 3 hours per week. Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours). Note: BTEC 3P50, BCHM 3P02, BIOL 3P80 and MATH 1P98 are recommended. #BTEC 4P08 Topics in Plant and Microbial Biotechnology (also offered as BCHM 4P08 and BIOL 4P08) Characterization of biochemical processes and structures. Genetic modification of such processes and structures through molecular manipulation to meet scientific and/or societal needs. Examples include yeast and microbial enzymes or enzyme systems as well as crop proteins and enzymes. Lectures, seminar, 3 hours per week. Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours). Prerequisite: one of BTEC 3P50, 3P63, BCHM 3P01, 3P02 or permission of the instructor. #BTEC 4P09 Transduction Pathways (also offered as BIOL 4P09 and BCHM 4P09) Perception of stimuli to effects on gene expression, emphasizing the molecular/biochemical tools used to study these pathways. Lectures, seminar, 3 hours per week. Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours). Prerequisite: BCHM 3P01. #BTEC 4P18 Computational Chemistry: Applications in Biotechnology (also offered as CHEM 4P18) Structure-based drug design, molecular modelling, conformational search techniques, secondary and tertiary protein structure prediction, quantitative structure activity relationships and bioinformatics. Lectures, 3 hours per week. Restriction: students must have a minimum of 13.5 overall credits. Prerequisite: BTEC 2P63 or CHEM 2P12. #BTEC 4P21 Mutagenesis in Disease and Biotechnology (also offered as BCHM 4P21 and BIOL 4P21) Exploration of the various mechanisms of mutagenesis of the genetic material, how they contribute to disease and how they can be adapted to produce new biomolecules. Lectures/seminar, 3 hours per week. Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours). Prerequisite: BTEC 3P50 or BCHM 3P02. #BTEC 4P27 Enzyme and Co-enzyme Mechanisms (also offered as CHEM 4P27) Hydrolytic and other processes catalyzed by enzymes lacking non-protein prosthetic groups; transferase reactions involving biotin, pyridoxal phosphate, thiamine pyrophosphate, folic acid and cobalamin; oxidation mechanisms involving pyridine nucleotides, flavoenzymes, hydroperoxidases and oxygenases. Lectures, seminar, 3 hours per week. Prerequisites: BCHM 3P01, 3P02 and CHEM 2P21. #BTEC 4P51 Molecular Virology (also offered as BIOL 4P51) Bacterial and animal viruses. Topics include biochemical properties, virus-host interaction, productive cycle, effect of virus on host cell and organism, viral vectors and gene therapy, recombinant viral vaccines and origin of virus. Lectures, seminar, 2 hours per week. Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours). Prerequisite: BTEC 3P50 or permission of the instructor. #BTEC 4P57 Bacterial Genetics (also offered as BIOL 4P57) Molecular and transmission genetics of bacteria. Bacterial genetics from early descriptions of transformation and transduction to current developments in molecular genetics. Lectures, seminar, 3 hours per week. Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours). Prerequisites: BTEC 3P50 and BIOL 2P98 or permission of the instructor. #BTEC 4P58 Fungal Genetics (also offered as BIOL 4P58) Transmission and molecular genetics of fungi. Recent advances in gene manipulation and the contribution of studies on these organisms to general genetic principles. Lectures, seminar, 2 hours per week. Restriction: students must have a minimum of 14.0 overall credits or approval to year 4 (honours). Prerequisite: one of BTEC 3P50, BIOL 2P96, 3P51 or permission of the instructor. #BTEC 4P67 Biophysical Techniques (also offered as BCHM 4P67 and CHEM 4P67) Modern instrumental methods of biotechnology emphasizing understanding theory. Development of newer technologies which utilize biological components. Topics include optical, X-ray and NMR techniques, separation techniques, hybridization assays, immunoassays, biosensors and mass spectral techniques; membrane chemistry. Lectures, seminar, 3 hours per week. Prerequisites: BTEC 2P63 and CHEM 2P21 or permission of the instructor. #BTEC 4P68 Biotransformations (also offered as CHEM 4P68) The organic reactions carried out by isolated enzymes, fungal cultures and bacteria. The production of pharmaceutical, agricultural and industrial chemicals by biological processes. Lectures, 3 hours per week. Prerequisite: one of BTEC 3P62, 3P63, CHEM 3P20 or permission of the instructor.  
CO-OP COURSES Go to top of document
BTEC 0N01 Work Placement I First Co-op work placement (4 months) with an approved employer. Restriction: open to BTEC Co-op students. BTEC 0N02 Work Placement II Second Co-op work placement (4 months) with an approved employer. Restriction: open to BTEC Co-op students. BTEC 0N03 Work Placement III Third Co-op work placement (4 months) with an approved employer. Restriction: open to BTEC Co-op students. BTEC 0N04 Work Placement IV Optional Co-op work placement (4 months) with an approved employer. Restriction: open to BTEC Co-op students. BTEC 0N05 Work Placement V Optional Co-op work placement (4 months) with an approved employer. Restriction: open to BTEC Co-op students.  
Last updated: June 23, 2006 @ 01:41PM