Enzyme-mediated cross-linking of silicone polymers

Enzyme-mediated cross-linking of silicone polymers

Project No. 2025

Principal Investigator/Inventor: Dr. Paul Zelisko, Department of Chemistry

A novel method for enzyme-mediated cross-linking of silicone polymers

The inventors have devised a novel method to use biological enzymes to convert readily available silicon based feedstock into reactive monomers for the formation of silicone polymers. The reactive monomers are are stable indefinitely at room temperature (in the absence of light or air) but can be rapidly cured to form materials that can be extruded or moulded resulting in a material with inertness of glass. The monomers can also be formed before curing and can be painted onto surfaces to provide an inert surface coating. Applications for this process may include providing coatings for closures that acts as a barrier for the transfer of undesired compounds into wine and additional applications in medical field, manufacturing sector, etc.

Patent Status

Zelisko, P.M., et al., “Enzyme-mediated cross-linking of silicone polymers” US application 12/664195; PCT application PCT/CA2008/001150.


Zelisko, P.M., et al., (2010) “Trypsin-Catalyzed Cross-Linking of Triethoxysilyl-Terminated Polydimethylsiloxane: An Experimental and Computational Approach.” in Advance of Silicones and Silicone-Modified Materials. Clarson, SJ., et al., eds. Chapter 5, 47-57, American Chemical Society.


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