Bold New Brock

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Publications

Publications (*corresponding author)
Independent publications
  1. Trimerization of alkynes, manuscript under preparation.
  2. Meso-substituted BODIPY sensors for ions, manuscript under preparation.
  3. Yang, L.; Li, J.; Simionescu, R.; Yan, H*. Observation of two N2-isobutyrylguanine tautomers by NMR spectroscopy, Magn. Reson. Chem. accepted.
  4. Dhruval, J.; Mitchell, M.; Bruce, D.; Lough, A.; Yan, H.* Synthesis of cyclic azobenzene analogues, Tetrahedron, 2012, 68, 8670.
  5. Zhou, N.; Wang, Q.; Lough, A.; Yan, H.* Preparation of (Z)-1,2-dichloroalkenes from terminal alkynes, Can. J. Chem. 2012, 90, 625.
  6. Yang, L.; Yan, H.* A Mannich-type reaction at the meso-methyl position of the BODIPY fluorophore, Synlett. 2012, 23, 1526.
  7. Cheng, H-J; Yan, H.; Sun, Y-L; Lu, C-Y; Huang, T-Y; Chen, S-J; Hu, C-H; Wu, Y-Y; Wu, A-T.* A simple and highly selective receptor for iodide in aqueous solution, Analyst 2012, 137, 571.
  8. Yang, L.; Simionescu, R.; Lough, A.; Yan, H.* Some observations relating to the stability of the BODIPY fluorophore under acidic and basic conditions, Dyes Pigments 2011, 91, 264.
  9. Zhao L, KuoLee R, Harris G, Tram K, Yan H, Chen W.* c-di-GMP protects against intranasal Acinetobacter baumannii infection in mice by chemokine induction and enhanced neutrophil recruitment, Int. Immunopharmacol. 2011, 11, 1378.
  10. Tram, K.; Sangvi, Y.; Yan, H.* Further studies on the detritylation in solid phase oligodeoxyribonucleotide synthesis, Nucleoside, Nucleotides & Nucleic Acids. 2011, 30, 12.
  11. Tram, K.; Twohig, D.; Yan, H.* Oligonucleotide labeling using BODIPY phosphoramidite, Nucleoside, Nucleotides & Nucleic Acids. 2011, 30, 1.
  12. Chen, W.*; Patel, G.; Yan, H. Zhang, J. Recent advances in the development of novel mucosal adjuvants and antigen delivery systems, Human Vaccines, 2010, 6, 683.
  13. Yan, H.*; Chen, W. 3’,5’-Diguanylic acid-a small nucleotide that makes big impact, Chem. Soc. Rev. 2010, 39, 2914.
  14. KuoLee, R.; Yan, H.; Chen, W.* cdiGMP as a mucosal vaccines adjuvant. Vaccine, 2010, 28, 3080.
  15. Zhao, Y.; Tram, K.; Yan, H.* Synthesis and characterization of mannosylated oligoribonucleotides, Carbohydrate Res. 2009, 344, 2137.
  16. Yan, H.;* KuoLee, R.; Tram, K.; Qiu, H.; Zhang, J.; Patel, G.B.; Chen, W.* Intranasal immunization of mice with bacterial second messenger cdiGMP elicits protective immunity against nasopharyngeal carriage of Streptococcus pneumoniae, Biochem. Biophys. Res. Commun. 2009, 387, 581.
  17. Tram, K.; Yan, H.;* Jenkins, H.; Vassiliev, S.; Bruce, D. The synthesis and crystal structure of unsubstituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY), Dyes Pigm. 2009, 82, 392.
  18. Tram, K.; McIntosh, W.; Yan, H*. Synthesis of glycosyl dipyrromethanes, Tetrahedron Lett. 2009, 50, 2278.
  19. Yan, H.;* Wang, X.; Kuolee, R.; Chen, W. Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP, Bioorg. Med. Chem. Lett. 2008, 18, 5631.
  20. Tram, K.; Wang, X.; Yan, H.* Facile synthesis of oligonucleotide phosphoroselenoates, Org. Lett. 2007, 9, 5103.
  21. Yan, H.;* Anguilar, A. L.; Zhao, Y. Preparation of carbohydrate–oligonucleotide conjugates using the squarate spacer, Bioorg. Med. Chem. Lett. 2007, 17, 6535.
  22. Yan, H.;* Anguilar, A. L. Synthesis of 3’,5’-cyclic diguanylic acid (cdiGMP), Nucleoside, Nucleotides & Nucleic Acids 2007, 26, 189.
  23. Yan, H.;* Tram, K. Glycotargeting to improve cellular delivery efficiency of nucleic acids, Glycoconjug. J. 2007, 24, 107.
 
Other independent publications
  1. Yan, H.; Tram, K. Compounds for fluorescent labelling. United States Provisional Patent No. 61/385913. Filed on September 22, 2010.
  2. Tram, K.; Jenkins, H. A.; Yan, H.* (2010) Private communication to the Cambridge Structural Database, deposition number CCDC 793318.
  3. Millar, S; Yan, H.; Sanghvi, Y. S.; Pon, R. Some observations on detritylation in solid-phase oligonucleotide synthesis. Nucleic Acids Symp. Ser. 2008, 52, 311.
  4. Zhao, Y.; Yan, H. Preparation of Mannosylated Oligoribonucleotides, Nucleic Acids Symp. Ser. 2008, 52, 89.
  5. Yan, H.; Humes, E. Convenient synthesis of 3’,5’-cyclic diguanylic acid (cdiGMP), Nucleic Acids Symp. Ser. 2006, 50, 5.
 
Post-doctoral and graduate publications
29. Yan, H.; Jennings, H. J. Synthesis of mono- and di-sialophospholipids via the H-phosphonate approach, Can. J. Chem. 2006, 84, 540.
30. Reese, C. B.; Yan, H. Alternatives to the 4,4'-dimethoxytrityl (DMTr) protecting group, Tetrahedron Lett. 2004, 45, 2567–2570.
31. Reese, C. B.; Yan, H. Further studies with adenosine 5'-dithiophosphoromorpholidate. A convenient preparation of nucleoside phosphorodithioates by a triester approach, Tetrahedron Lett. 2004, 45, 2653.
32. Reese, C. B.; Yan, H. An approach to the desulfurization of oligonucleotide phosphorothioates, Tetrahedron Lett. 2003, 44, 2501.
33. Reese, C. B.; Yan, H.Solution phase synthesis of ISIS 2922 (Vitravene) by the modified H-phosphonate approach. J. Chem. Soc., Perkin. Trans. 1 2002, 23, 2619.
34. Reese, C. B.; Yan, H. Xanthen-9-ylidene protecting groups in glycerol chemistry. J. Chem. Soc., Perkin Trans. 1 2001, 15, 1807.
35. Reese, C. B.; Yan, H. Reaction between pyrrole and orthoesters: preparation of tri-(pyrrole-2-yl)alkanes. Tetrahedron Lett. 2001, 42, 5545.
36. Reese, C. B.; Song, Q.; Yan, H. Xanthen-9-ylidene and 2,7-dimethylxanthen-9-ylidene protecting groups. Tetrahedron Lett. 2001, 42, 1789.
 
Department of Chemistry
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