Published on Brock University (http://www.brocku.ca)
Publications
2012
2009
Wen Xiao Zhang, Grant Frahm, Samantha Morley, Danny Manor and Jeffrey Atkinson. Effect of Bilayer Phospholipid Composition and Curvature on Ligand Transfer by the α-Tocopherol Transfer Protein. Lipids 2009 (in press) [PubMed]
V. E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G. G. Borisenko, Y. Y. Tyurina, P. Wipf, J. Atkinson, J. S. Greenberger, R. S. Chapkin and N. A. Belikova. Mitochondria-targeted disruptors and inhibitors of cytochrome c peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Molecular Nutrition and Food Research. 2009, 104-114 [PubMed]
2008
Stephan Ohnmacht, Phillip Nava, Ryan West, Robert Parker and Jeffrey Atkinson. Inhibition of oxidative metabolism of tocopherols with ω−N-heterocyclic derivatives of vitamin E. Bioorganic & Medicinal Chemistry, 2008, 16(16), 7631-7638. [PubMed]
Samantha Morley, Matt Cecchini, Wendy Zhang, Alessandro Virgulti, Noa Noy, Jeffrey Atkinson, and Danny Manor. Mechanisms of ligand transfer by the hepatic Tocopherol Transfer Protein. J Biol Chem 2008 283(26): 17797–17804 [PubMed]
Jan Frank, Sangeun Lee, Scott W. Leonard, Jeffrey K. Atkinson, Afaf Kamal-Eldin, and Maret G. Traber. Gender differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am. J. Clin. Nutr. 2008, 87(6):1723-9 [PubMed]
Matthew A. Churchward, Tatiana Rogasevskaia, David M. Brandman, Houman Khosravani,
Phillip Nava, Jeffrey K. Atkinson, and Jens R. Coorssen. Specific lipids supply critical negative spontaneous curvature ― an essential component of native Ca2+-triggered membrane fusion. Biophys. J. 2008, 94(10):3976-86 [PubMed]
Jeffrey Atkinson, Raquel F. Epand, Richard M. Epand. Tocopherols and Tocotrienols in Membranes: A Critical Review. Free. Rad. Biol. Med. 2008 44, 739-764. [PubMed]
Stephan Ohnmacht1, Ryan West, Razvan Simionescu, Jeffrey Atkinson. Assignment of the 1H- and 13C-NMR of Tocotrienols. Mag. Res. Chem. 2008 46(3), 287-294. [PubMed]
2007
Tae-gyu Nam, Christopher L. Rector, Hye-young Kim, Andreas F.-P. Sonnen, Roland Meyer, Werner M. Nau, Jeffrey Atkinson, Julia Rintoul, Derek A. Pratt, and Ned A. Porter. Tetrahydro-1,8-naphthyridinol Analogues of -Tocopherol as Antioxidants in Lipid Membranes and Low-Density Lipoproteins. J. Am. Chem. Soc. 2007, 129(33), 10211 - 10219 [PubMed]
Maret G. Traber and Jeffrey Atkinson. Vitamin E, anrtioxidant and nothing more. Free Rad Biol Med 2007 43, 4-15. (Invited Review) [PubMed]
2006
Qian J, Atkinson J, Manor D. Biochemical consequences of heritable mutations in the alpha-tocopherol transfer protein. Biochemistry. 2006 45(27):8236-42. [PubMed]
Nava P, Cecchini M, Chirico S, Gordon H, Morley S, Manor D, Atkinson J.
Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer protein. Bioorg Med Chem. 2006, 14(11):3721-36. [PubMed]
Jun Li, Martin C. Henmana, Jeffrey Atkinson, Solomon Fixon-Owoo, Turgut Tatlisumak, Graham G. Shaw, Karen M. Doyle, The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice. 2006, Brain Research, 1076(1), 209-215.
Richard S. Bruno, Scott W. Leonard, Jeffery Atkinson, Thomas J. Montine, Rajasekhar Ramakrishnan, Tammy M. Bray, Maret G. Traber. Faster plasma Vitamin E disappearance in smokers is normalized by vitamin C supplementation. 2006 Free Radical Biology & Medicine 40, 689 – 697. [PubMed]
Samantha Morley, Valerie Curtis, Matt Cecchini, Phil Nava, Jeffrey Atkinson, and Danny Manor. Utility of a fluorescent Vitamin E analog as a probe for tocopherol transfer protein activity. Biochemistry 2006 45(4), 1075-1081. [PubMed]
2005
Scott W. Leonard, Elaine Paterson, Jeffrey Atkinson, Rajasekhar Ramakrishnan, Carroll E. Cross, & Maret G. Traber. Studies in humans using deuterium-labeled alpha– and gamma–tocopherols demonstrate faster plasma gamma–tocopherol disappearance and greater metabolite production. Free Radic Biol Med. 2005 38(7):857-66. [PubMed]
Qian J, Morley S, Wilson K, Nava P, Atkinson J, Manor D. Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein. Lipid Res. 2005, 46(10):2072-82. [PubMed]
2004
Morley S, Panagabko C, Stocker A, Atkinson J, Manor D. Structure-function relationship in the tocopherol transfer protein. Ann N Y Acad Sci. 2004 1031:332-3.
Qian J, Wilson K, Nava P, Morley S, Atkinson J, Manor D. Intracellular Localization of {alpha}-Tocopherol Transfer Protein and alpha-Tocopherol. Ann N Y Acad Sci. 2004 1031:330-1.
Atkinson JK, Nava P, Frahm G, Curtis V, Manor D. Fluorescent Tocopherols as Probes of Inter-Vesicular Transfer Catalyzed by the alpha-Tocopherol Transfer Protein. Ann N Y Acad Sci. 2004 1031:324-7.
Lawson KA, Anderson K, Simmons-Menchaca M, Atkinson J, Sun L, Sanders BG, Kline K.
Comparison of vitamin E derivatives alpha-TEA and VES in reduction of mouse mammary tumor burden and metastasis. Exp Biol Med. 2004, 229(9), 954-63. [PubMed]
Samantha Morley, Candance Panagabko, Diana Shineman, Achim Stocker, Jeffrey Atkinson and Danny Manor. Molecular Determinants of Heritable Vitamin E Deficiency. Biochemistry 2004, 43, 4143-4149. [PubMed]
Ming-Chieh Shun, Weiping Yu, Jeffrey Atkinson, Abdul Gapor, Bob G. Sanders, and Kimberly Kline Pro-apoptotic Mechanisms of Action of a Novel Vitamin E Analog (alpha-TEA) and a Naturally Occurring Form of Vitamin E (delta-Tocotrienol) in MDA-MB-435 Human Breast Cancer Cells. Nutrition and Cancer 2004, 48(1), 95-105
Lawson KA, Anderson K, Snyder RM, Simmons-Menchaca M, Atkinson J, Sun LZ, Bandyopadhyay A, Knight V, Gilbert BE, Sanders BG, Kline K. Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis. Cancer Chemother Pharmacol. 2004 54(5):421-31 [PubMed]
Scott W. Leonard, Richard S Bruno, Elaine Paterson, Bettina Schock, Jeffrey Atkinson, Tammy M. Bray, Carroll E Cross, and Maret G. Traber. 5-Nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in-vitro and in-vivo. Free Radicals in Biology and Medicine 2003, 35(12):1560-7. [PubMed]
2003
Galli F, Lee R, Atkinson J, Floridi A, Kelly FJ. Gamma-Tocopherol biokinetics and transformation in humans. Free Radic Res. 2003, 37(11):1225-33. [PubMed]
Bradford A, Atkinson J, Fuller N, Rand RP. The effect of vitamin E on the structure of membrane lipid assemblies. J Lipid Res. 2003, 44(10):1940-5. [PubMed]
Lawson KA, Anderson K, Menchaca M, Atkinson J, Sun LZ, Knight V, Gilbert B, Conti C, Sanders BS, Kline K. Novel Vitamin E Analog Inhibits Syngeneic Mouse Mammary Tumor Growth and Blocks Lung Metastasis. Molecular Cancer Therapeutics. 2003 Molecular Cancer Therapeutics. 2003, 2, 437-444. [PubMed]
Candace Panagabko, Samantha Morley, Marta Hernandez, Patrick Cassolato, Heather Gordon, Rachel Parsons, Danny Manor and Jeffrey Atkinson. Ligand specificity in the CRAL-TRIO protein family. Biochemistry 2003, 42(21), 6467-6474 [PubMed]
Solomon Fixon-Owoo, Frédéric Levasseur, Keith Williams, Thomas N. Sabado, Mike Lowe, Markus Klose, A. Joffre Mercier, Paul Fields, Jeffrey Atkinson. Preparation and Biological Assessment of Hydroxycinnamic Acid Amides of Polyamines In press: Phytochemistry 2003, 63(3):315-34.
2002
Panagabko, C., Neely, S., Lei, H., Morley, S., Manor, D., and Atkinson, J. Expression and refolding of recombinant human alpha-tocopherol transfer protein (alpha-TTP) capable of specific alpha-tocopherol binding. Protein Expression and Purification. 2002 , 24, 395-403
Klose, M.K., Atkinson, J.K., and Mercier, A.J. Effects of a hydroxycinnamoyl conjugate of spermidine on arthropod neuromuscular junctions. J Comp Physiol A, 187:945-952, 2002
1991-2001
Galli, F., Lee, R., Dunster, C., Atkinson, J.K., Floridi, A., and Kelly, F.J. Gamma-tocopherol metabolism and its relationship with alpha-tocopherol in humans: a stable isotope supplementation study. Biofactors 2001 15(2-4), 65-69
Lei, Huangshu; Jeffrey Atkinson. Hydrogen-deuterium scrambling during the reductive deuteration of alpha- and gamma-tocopherol chromenes Journal of Labeled Compounds and Radiopharmaceutical. 2001, 44, 215-223.
Lei, Huangshu,; Atkinson, J.K. Synthesis of phytyl and chroman derivatized photoaffinity labels based on a-tocopherol. Journal of Organic Chemistry. 2000, 65(8); 2560-2567.
Panagabko, C.; Chenier, D.; Fixon-Owoo, S.; Atkinson, J.K. Ion-pair HPLC determination of hydroxycinnamic acid monoconjugates of putrescine, spermidine and spermine. Phytochemical Analysis , 2000, 11, 11-17.
Lei, H.; Marks, V.; Pasquale, T.; Atkinson, J.K. Synthesis of photoaffinity label analogues of a-tocopherol. Bioorg. Med. Chem. Letters, 1998 8, 3453-3458.
Mercier, A. Joffre; Farragher, Suzanne; Schmor, B.; Kamau, M.; Atkinson, J. Effect of a plant derived spider-toxin analogue on the crayfish neuromuscular junctions. Canadian Journal of Zoology, 1998, 76, 2103-2107.
Tays, K.; Atkinson, J.K. An improved synthesis of cyclic hydroxamic acids from Gramineae. Synthetic Communications, 1998 28(5), 903-912.
Sen, A.; Bergvinson, D.; Miller, S; Atkinson,J.K.; Fulcher, G.; Arnanson, J.T. Distribution and microchemical detection of phenolic acids, flavanoids and phenolic acid amides in maize kernels. J. Chem. Ecol. 1994 42, 1879-1883
Palli, S. R.; Touhara, K; Charles, J.-P.; Bonning, B.C.; Atkinson, J.K.; Trowell, S. C.; Hiruma, K.; Goodman, W.G.; Kyriakides, T; Prestwich, G.D.; Hammock, B. D. and Riddiford, L.M. A nuclear juvenile hormone binding protein from larvae of Manduca sexta: A putative receptor for the metamorphic action of juvenile hormone. Proceedings of the National Academy of Science USA, 1994, 91, 6191-6195.
J.K. Atkinson, J. Arnason, F. Campos, H.M. Niemeyer, H.R. Bravo, "Synthesis and Reactivity of Cyclic Hydroxamic Acids: Resistance Factors in the Gramineae", Chapter 32 in Synthesis and Chemistry of Agrochemicals, Vol. III, ed. by D.R. Baker, J.G. Fenyes and J.J. Steffens, ACS Symposium Series, 504, 349-360 ( 1992 ).
J. Atkinson, P. Morand, J.T Arnason, H.M. Niemeyer, H. Bravo, "Synthesis of Analogues of the Cyclic Hydroxamic Acid 2,4-Dihydroxy- 7-Methoxy-1,4-Benzoxazin-3-One (DIMBOA): Their pH Dependent Decomposition and Reaction with Mercaptoethanol", J. Org. Chem., 56, 1788-1800 ( 1991 ).
