Published on Brock University (http://www.brocku.ca)
Synthesis and activity of novel C-1 analogs of pancratistatin and 7-deoxypancratistatin
New potent derivation produces pancratistatin analogs.
Description
Pancratistatin (PN) occurs naturally in the Hawaiian Spider Lily and is known to be highly active against cancer cell lines as an apoptosis stimulator; it is capable of inducing apoptosis (programmed cell death) in cancer cells while having no effect on normal cells. A drug of this kind would not have many of the negative side effects associated with cancer treatments that effect healthy cells (ie. hair loss, weakened immunity). Since its first synthesis in 1995, Hudlicky’s research group has focused on producing a variety of derivatives with more desirable bioavailability and solubility. The present technology describes 2 novel analogs of PN and 7-deoxyPN. The products are able to selectively induce apoptosis in human cancer cell lines: including leukemia, neuroblastoma and melanoma cells.
Potential Benefits
• Development of more potent and bioavailable cancer agents
Novelty
The inventors created 2 new, unnatural derivatives of 7-deoxyPN with activities approaching that of natural PN.
Development Stage
(information forthcoming)
Patent Status: Provisional Patent Filed
Inventor(s):
Tomas Hudlicky, Professor, Chemistry, Brock
Jonathan Collins, Grad student, Chemistry, Brock
Melissa Drouin, Grad student, Chemistry, Brock
