Published on Brock University (http://www.brocku.ca)
In my lab, we investigate the regulation of muscle metabolism in response to diet and exercise in various models. In the past we have focussed specifically on the regulation of the skeletal muscle pyruvate dehydrogenase (PDH) enzyme complex and its important kinase and phosphatase enzymes. These regulatory enzymes respond differently to long term perturbations that shift fuel utilization towards increasing fat oxidation (i.e., endurance training, starvation, high fat diets).
More recently, we have started to explore the regulation of lipid metabolism in muscle. For example, we are exploring the roles of the proteins that coat lipid droplets known as "PLIN proteins" that may be of importance in regulation of intramuscular triglyceride breakdown and synthesis.
Studying the regulation of fat and carbohydrate use leads to a better understanding of the underlying mechanisms of disorders such as insulin resistance and diabetes, and how potential exercise therapies can ameliorate the condition.