Publications

Department of Chemistry




Publications

 2012

 
Christine A. McCary, Youngdae Yoon, Candace Panagabko, Wonhwa Cho, Jeffrey Atkinson, and Joan M. Cook-Mills. Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα. Biochemical Journal, 2012, 441, 189-198 [PubMed]
 
2011
 
Ulatowski, L., Parker, R., Davidson, C., Yanjanin, N., Kelley, T. J., Corey, D., Atkinson, J., Porter, F., Arai, H., Walkley, S. U., and D. Manor. Altered vitamin E status in Niemann-Pick type C disease. J. Lipid. Res., 2011,52,1400–1410. [PubMed]
 
Jeffrey Atkinson, Alexandr A. Kapralov, Naveena Yanamala, Linda Pierce, James Peterson, Yulia Y. Tyurina, Michael Epperly, Zhentai Huang, Jianfei Jiang, Akihiro Maeda, Weihong Feng, Karla Wasserlos, Natalia A. Belikova, Vladimir A. Tyurin, Jackie Fletcher, Yongsheng Wang, Judith Klein-Seetharaman, Detcho A. Stoyanovsky, Hülya Bayîr, Bruce R. Pitt, Joel S. Greenberger, Valerian E. Kagan. A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nature Communications 2, 2011, Article number: 497 (doi:10.1038/ncomms1499). [PubMed]
 
Nishio, K., Ishida, N., Saito, Y., Ogawa-Akazawa, Y., Shichiri, M., Yoshida, Y., Hagihara, Y., Noguchi, N., Chirico, J., Atkinson, J., and Etsuo Niki. α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse Free Radical Biology and Medicine, 2011, 50(12), 1794–1800. [PubMed]
 
2010
 
Wen Xiao Zhang, Varsha Thakur, Andrei Lomize, Irina Pogozheva, Candace Panagabko, Matt Cecchini, Matilda Baptist, Samantha Morley, Danny Manor and Jeffrey Atkinson. The Contribution of Surface Residues to Membrane Binding and Ligand Transfer by the α-Tocopherol Transfer Protein (α-TTP). J. Mol. Biol. 2010, 405, 972-988. [PubMed]
 
Samantha Morley, Varsha Thakur, David Danielpour, Robert Parker, Hiroyuki Arai, Jeffrey Atkinson, Jill Barnholtz-Sloan, Eric Klein, and Danny Manor. The tocopherol transfer protein sensitizes prostate cancer cells to vitamin E. J. Biol. Chem. 2010, 285(46), 35578-35589. [PubMed]
 
Ryan West, Candace Panagabko, and Jeffrey Atkinson. Synthesis and Characterization of BODIPY-α-Tocopherol: A Fluorescent Form of Vitamin E. J. Org. Chem. 2010, 75(9), 2883–2892. [PubMed]
 
Yongsheng Wang, Candace Panagabko, Jeffrey Atkinson. Synthesis of α-tocohexaenol (α-T6) a fluorescent, oxidatively sensitive polyene analogue of α-tocopherol. Bioorganic & Medicinal Chemistry. 2010 18, 777–786. [PubMed]
 
(Invited Review) Jeffrey Atkinson, Thad Harroun, Stephen R. Wassall, William Stillwell and John Katsaras. The location and behavior of α-tocopherol in membranes. Mol. Nutr. Food Res. 2010, 54, 1–11. [PubMed]
 

2009

Wen Xiao Zhang, Grant Frahm, Samantha Morley, Danny Manor and Jeffrey Atkinson. Effect of Bilayer Phospholipid Composition and Curvature on Ligand Transfer by the α-Tocopherol Transfer Protein.  Lipids 2009 (in press) [PubMed]

V. E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G. G. Borisenko, Y. Y. Tyurina, P. Wipf, J. Atkinson, J. S. Greenberger, R. S. Chapkin and N. A. Belikova.  Mitochondria-targeted disruptors and inhibitors of cytochrome c peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Molecular Nutrition and Food Research.  2009, 104-114 [PubMed]

2008

Stephan Ohnmacht, Phillip Nava, Ryan West, Robert Parker and Jeffrey Atkinson.  Inhibition of oxidative metabolism of tocopherols with ω−N-heterocyclic derivatives of vitamin E.  Bioorganic & Medicinal Chemistry, 2008, 16(16), 7631-7638. [PubMed]

Samantha Morley, Matt Cecchini, Wendy Zhang, Alessandro Virgulti, Noa Noy, Jeffrey Atkinson, and Danny Manor.  Mechanisms of ligand transfer by the hepatic Tocopherol Transfer Protein.  J Biol Chem 2008 283(26): 17797–17804 [PubMed]

Jan Frank, Sangeun Lee, Scott W. Leonard, Jeffrey K. Atkinson,  Afaf Kamal-Eldin, and Maret G. Traber. Gender differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects.  Am. J. Clin. Nutr. 2008, 87(6):1723-9 [PubMed]

Matthew A. Churchward, Tatiana Rogasevskaia, David M. Brandman, Houman Khosravani,
Phillip Nava, Jeffrey K. Atkinson, and Jens R. Coorssen.  Specific lipids supply critical negative spontaneous curvature ― an essential component of native Ca2+-triggered membrane fusion.  Biophys. J. 2008, 94(10):3976-86 [PubMed]

Jeffrey Atkinson, Raquel F. Epand, Richard M. Epand.  Tocopherols and Tocotrienols in Membranes: A Critical Review.  Free. Rad. Biol. Med. 2008 44, 739-764. [PubMed]

Stephan Ohnmacht1, Ryan West, Razvan Simionescu, Jeffrey Atkinson. Assignment of the 1H- and 13C-NMR of Tocotrienols.  Mag. Res. Chem. 2008  46(3), 287-294. [PubMed]

2007

Tae-gyu Nam, Christopher L. Rector, Hye-young Kim, Andreas F.-P. Sonnen, Roland Meyer, Werner M. Nau, Jeffrey Atkinson, Julia Rintoul, Derek A. Pratt, and Ned A. Porter.  Tetrahydro-1,8-naphthyridinol Analogues of -Tocopherol as Antioxidants in Lipid Membranes and Low-Density Lipoproteins. J. Am. Chem. Soc. 2007, 129(33), 10211 - 10219 [PubMed]

Maret G. Traber and Jeffrey Atkinson.  Vitamin E, anrtioxidant and nothing more.  Free Rad Biol Med 2007 43, 4-15. (Invited Review) [PubMed]

2006

Qian J, Atkinson J, Manor D.  Biochemical consequences of heritable mutations in the alpha-tocopherol transfer protein. Biochemistry. 2006 45(27):8236-42. [PubMed]

Nava P, Cecchini M, Chirico S, Gordon H, Morley S, Manor D, Atkinson J.
Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer protein. Bioorg Med Chem. 2006, 14(11):3721-36. [PubMed]

Jun Li, Martin C. Henmana, Jeffrey Atkinson, Solomon Fixon-Owoo, Turgut Tatlisumak, Graham G. Shaw, Karen M. Doyle, The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice.  2006, Brain Research, 1076(1), 209-215.

Richard S. Bruno, Scott W. Leonard, Jeffery Atkinson, Thomas J. Montine, Rajasekhar Ramakrishnan, Tammy M. Bray, Maret G. Traber.  Faster plasma Vitamin E disappearance in smokers is normalized by vitamin C supplementation.   2006 Free Radical Biology & Medicine 40, 689 – 697. [PubMed]

Samantha Morley, Valerie Curtis, Matt Cecchini, Phil Nava, Jeffrey Atkinson, and Danny Manor. Utility of a fluorescent Vitamin E analog as a probe for tocopherol transfer protein activity.  Biochemistry 2006   45(4), 1075-1081. [PubMed]

2005

Scott W. Leonard, Elaine Paterson, Jeffrey Atkinson, Rajasekhar Ramakrishnan, Carroll E. Cross, & Maret G. Traber. Studies in humans using deuterium-labeled alpha– and gamma–tocopherols demonstrate faster plasma gamma–tocopherol disappearance and greater metabolite production.  Free Radic Biol Med. 2005 38(7):857-66. [PubMed]

Qian J, Morley S, Wilson K, Nava P, Atkinson J, Manor D.  Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein.  Lipid Res. 2005, 46(10):2072-82. [PubMed]

2004

Morley S, Panagabko C, Stocker A, Atkinson J, Manor D. Structure-function relationship in the tocopherol transfer protein. Ann N Y Acad Sci. 2004 1031:332-3.

Qian J, Wilson K, Nava P, Morley S, Atkinson J, Manor D. Intracellular Localization of {alpha}-Tocopherol Transfer Protein and alpha-Tocopherol. Ann N Y Acad Sci. 2004 1031:330-1.

Atkinson JK, Nava P, Frahm G, Curtis V, Manor D. Fluorescent Tocopherols as Probes of Inter-Vesicular Transfer Catalyzed by the alpha-Tocopherol Transfer Protein. Ann N Y Acad Sci. 2004 1031:324-7.

Lawson KA, Anderson K, Simmons-Menchaca M, Atkinson J, Sun L, Sanders BG, Kline K.
Comparison of vitamin E derivatives alpha-TEA and VES in reduction of mouse mammary tumor burden and metastasis. Exp Biol Med. 2004, 229(9), 954-63. [PubMed]

Samantha Morley, Candance Panagabko, Diana Shineman, Achim Stocker, Jeffrey Atkinson and Danny Manor.  Molecular Determinants of Heritable Vitamin E Deficiency. Biochemistry 2004, 43, 4143-4149. [PubMed]

Ming-Chieh Shun, Weiping Yu, Jeffrey Atkinson, Abdul Gapor, Bob G. Sanders, and Kimberly Kline Pro-apoptotic Mechanisms of Action of a Novel Vitamin E Analog (alpha-TEA) and a Naturally Occurring Form of Vitamin E (delta-Tocotrienol) in MDA-MB-435 Human Breast Cancer Cells. Nutrition and Cancer 2004, 48(1), 95-105

Lawson KA, Anderson K, Snyder RM, Simmons-Menchaca M, Atkinson J, Sun LZ, Bandyopadhyay A, Knight V, Gilbert BE, Sanders BG, Kline K.  Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis.  Cancer Chemother Pharmacol. 2004 54(5):421-31 [PubMed]

Scott W. Leonard, Richard S Bruno, Elaine Paterson, Bettina Schock, Jeffrey Atkinson, Tammy M. Bray, Carroll E Cross, and Maret G. Traber. 5-Nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in-vitro and in-vivo. Free Radicals in Biology and Medicine 2003, 35(12):1560-7.  [PubMed]

2003

Galli F, Lee R, Atkinson J, Floridi A, Kelly FJ. Gamma-Tocopherol biokinetics and transformation in humans. Free Radic Res. 2003, 37(11):1225-33. [PubMed]

Bradford A, Atkinson J, Fuller N, Rand RP. The effect of vitamin E on the structure of membrane lipid assemblies. J Lipid Res. 2003, 44(10):1940-5. [PubMed]

Lawson KA, Anderson K, Menchaca M, Atkinson J, Sun LZ, Knight V, Gilbert B, Conti C, Sanders BS, Kline K. Novel Vitamin E Analog Inhibits Syngeneic Mouse Mammary Tumor Growth and Blocks Lung Metastasis. Molecular Cancer Therapeutics. 2003 Molecular Cancer Therapeutics. 2003, 2, 437-444. [PubMed]

Candace Panagabko, Samantha Morley, Marta Hernandez, Patrick Cassolato, Heather Gordon, Rachel Parsons, Danny Manor and Jeffrey Atkinson.   Ligand specificity in the CRAL-TRIO protein family. Biochemistry  2003, 42(21), 6467-6474 [PubMed]

Solomon Fixon-Owoo,  Frédéric Levasseur,  Keith Williams, Thomas N. Sabado, Mike Lowe, Markus Klose, A. Joffre Mercier, Paul Fields, Jeffrey Atkinson.  Preparation and Biological Assessment of Hydroxycinnamic Acid Amides of Polyamines In press: Phytochemistry 2003, 63(3):315-34.

2002

Panagabko, C., Neely, S., Lei, H., Morley, S., Manor, D., and Atkinson, J. Expression and refolding of recombinant human alpha-tocopherol transfer protein (alpha-TTP) capable of specific alpha-tocopherol binding.  Protein Expression and Purification. 2002 , 24, 395-403

Klose, M.K., Atkinson, J.K., and Mercier, A.J.  Effects of a hydroxycinnamoyl conjugate of spermidine on arthropod neuromuscular junctions. J Comp Physiol A, 187:945-952, 2002

1991-2001

Galli, F., Lee, R., Dunster, C., Atkinson, J.K., Floridi, A.,  and Kelly, F.J.  Gamma-tocopherol metabolism and its relationship with alpha-tocopherol in humans: a stable isotope supplementation study. Biofactors 2001 15(2-4), 65-69

Lei, Huangshu; Jeffrey Atkinson. Hydrogen-deuterium scrambling during the reductive deuteration of alpha- and gamma-tocopherol chromenes Journal of Labeled Compounds and Radiopharmaceutical. 2001, 44, 215-223.

Lei, Huangshu,; Atkinson, J.K. Synthesis of phytyl and chroman derivatized photoaffinity labels based on a-tocopherol. Journal of Organic Chemistry. 2000, 65(8); 2560-2567.

Panagabko, C.; Chenier, D.; Fixon-Owoo, S.; Atkinson, J.K. Ion-pair HPLC determination of hydroxycinnamic acid monoconjugates of putrescine, spermidine and spermine. Phytochemical Analysis , 2000, 11, 11-17.

Lei, H.; Marks, V.; Pasquale, T.; Atkinson, J.K. Synthesis of photoaffinity label analogues of a-tocopherol. Bioorg. Med. Chem. Letters, 1998 8, 3453-3458.

Mercier, A. Joffre; Farragher, Suzanne; Schmor, B.; Kamau, M.; Atkinson, J. Effect of a plant derived spider-toxin analogue on the crayfish neuromuscular junctions. Canadian Journal of Zoology, 1998, 76, 2103-2107.

Tays, K.; Atkinson, J.K. An improved synthesis of cyclic hydroxamic acids from Gramineae. Synthetic Communications, 1998 28(5), 903-912.

Sen, A.; Bergvinson, D.; Miller, S; Atkinson,J.K.; Fulcher, G.; Arnanson, J.T. Distribution and microchemical detection of phenolic acids, flavanoids and phenolic acid amides in maize kernels. J. Chem. Ecol. 1994 42, 1879-1883

Palli, S. R.; Touhara, K; Charles, J.-P.; Bonning, B.C.; Atkinson, J.K.; Trowell, S. C.; Hiruma, K.; Goodman, W.G.; Kyriakides, T; Prestwich, G.D.; Hammock, B. D. and Riddiford, L.M. A nuclear juvenile hormone binding protein from larvae of Manduca sexta: A putative receptor for the metamorphic action of juvenile hormone. Proceedings of the National Academy of Science USA, 1994, 91, 6191-6195.

J.K. Atkinson, J. Arnason, F. Campos, H.M. Niemeyer, H.R. Bravo, "Synthesis and Reactivity of Cyclic Hydroxamic Acids: Resistance Factors in the Gramineae", Chapter 32 in Synthesis and Chemistry of Agrochemicals, Vol. III, ed. by D.R. Baker, J.G. Fenyes and J.J. Steffens, ACS Symposium Series, 504, 349-360 ( 1992 ).

J. Atkinson, P. Morand, J.T Arnason, H.M. Niemeyer, H. Bravo, "Synthesis of Analogues of the Cyclic Hydroxamic Acid 2,4-Dihydroxy- 7-Methoxy-1,4-Benzoxazin-3-One (DIMBOA): Their pH Dependent Decomposition and Reaction with Mercaptoethanol", J. Org. Chem., 56, 1788-1800 ( 1991 ).

POSTAL ADDRESS
Dept. of Chemistry
Brock University
500 Glenridge Ave.
St. Catharines, ON
Canada, L2S 3A1
Tel: (905) 688-5550 x3406

Administrative Assistant:
Christine Skorski
cskorski@brocku.ca

Webmaster:
Razvan Simionescu
rsimionescu@brocku.ca