Dr. Jeffrey A. Stuart

Dr. Jeffrey A. Stuart

CCOVI Fellow
Associate Professor of Biological Sciences
Faculty of Mathematics and Science, Brock University, St. Catharines, Ont.
Email: jstuart@brocku.ca
Phone: 905-688-5550 x4814
Fax: 905-688-1855
Office: MC F224

Education
BSc in Biology, University of Guelph, Guelph, Ont.
PhD in Zoology, University of Guelph, Guelph, Ont.

Teaching
Human Physiology
Cell Physiology
Bioenergetics

Research
Biological activities of resveratrol and other red-wine polyphenols.
Molecular mechanisms underlying longevity.

Selected Publications and Presentations

  • Kronenberg, G., Gertz, K., Overall, R.W., Harms, C., Klein, J., Page, M.M., Stuart, J.A., Endres, M., 2011.  Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase.  Exptl. Neurol.  In press.
  • Salway, K.D., Gallagher, E.J. and Stuart, J.A., 2011.  Longer-lived mammals and birds have higher levels of heat shock proteins.  Mech. Age. Devel.  In press.
  • Robb, E.L. and Stuart, J.A., 2011.  Resveratrol interacts with estrogen receptor-β to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase.  Free Radic. Biol. Med.  In press.
  • Stuart, J.A. and Page, M.M., 2010.  Plasma [IGF-1] is negatively correlated with body mass in a comparison of 36 mammalian species.  Mech. Age. Devel.131, 591-598.
  • Salway, K.D. and Stuart, J.A., 2010.  Antioxidant enzymes and oxidative damage biomarkers in heart and selected other tissues of estivating and arousing land snails (Achatina fulica). Comp. Biochem. Physiol. 157, 229-36.
  • Salway, K.D., Page, M. M., Faure, P.A., Burness, G. and Stuart, J.A., 2010.Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species.  AGE.  Published online Jun 22.
  • Robb. E.L. and Stuart, J.A., 2010. trans-Resveratrol as a neuroprotectant. Molecules 15, 1196-1212.
  • Page, M.M., Robb, E.L., Salway, K.D., and Stuart, J.A., 2010. Mitochondrial redox metabolism: aging, longevity and dietary effects.  Mech. Ageing and Devel.  131, 242-252.
  • Page, M.M., Richardson, J., Wiens, B.E., Tiedtke, E., Peters, C.W., Faure, P.A., Burness, G. and Stuart, J.A., 2010.  Antioxidant enzyme activities are not broadly correlated with longevity in 14 endotherm species. AGE.  32, 255-270.
  • Page, M.M., Salway, K.D., Ip, Y.K., Chew, S.F., Warren, S.A., Ballantyne, J.S. and Stuart, J.A., 2010.  Upregulation of intracellular antioxidant enzymes in brain and heart during estivation in the African lungfish Protopterus dolloi.  J. Comp. Physiol. B 180, 361-369.
  • Stuart presented "Discovering the biological activities of resveratrol - an emerging nutraceutical" at the research café "Curing what ails us - from discovery to market" during the 3-part series "Mapping the New Knowledge" organized by the Grad Students' Association at Brock University, St. Catharines, March 2010.
  • Page, M.M, Salmon, A.B., Leiser, S.F., Robb, E.L., Brown, M.F., Miller, R.A. and Stuart, J.A. 2009.  Mechanisms of stress resistance in Snell dwarf mouse fibroblasts:  enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism.  Free Radic. Biol. Med46,1109-1118.
  • Robb, E.L., Page, M.M. and Stuart, J.A., 2009.  Mitochondria, cellular stress resistance, somatic cell depletion and lifespan.  Current Aging Science 1, 12-27.
  • Robb, E.L., P. Zelisko, and J.A. Stuart presented "MnSOD plays an important role in resveratrol's biological effects" at the Society for Free Radical Biology and Medecine Annual Conference in San Francisco in Nov. 2009.
  • Robb, E.L., P. Zelisko, and J.A. Stuart presented " Polyphenols: resveratrol targets the mitochondrial antioxidant enzyme manganese superoxide dismutase and increase cellular stress resistance. Polyphenols in human health" in Harrogate, UK in Dec. 2009.
  • Stuart, J.A. 2009. Editor of Mitochondrial DNA: Methods and Protocols, 2nd edition. Volume 197 In: Methods in Molecular Biology, Human Press, Totowa, New Jersey.
  • Page, M.M, A.B. Salmon, S.F. Leiser, E.L. Robb, M.F. Brown, R.A. Miller, and J.A. Stuart. 2009. Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism. Free Radic. Biol. Med, 46, 1109-1118.
  • Robb, E.L., M.M. Page, and J.A. Stuart. 2009. Mitochondria, cellular stress resistance, somatic cell depletion and lifespan. Curr. Aging Sci., 1, 12-27.
  • Page, M.M., Peters, C.W., Staples, J.F. and Stuart, J.A., 2009. Intracellular superoxide dismutases are not altered during hibernation in the 13-lined ground squirrel Spermophilus tridecemlineatus. Comp. Biochem. Physiol. A Mol. Integr. Physiol.152,115-22.
  • Page, M.M. and Stuart, J.A. In vitro measurement of mitochondrial DNA base excision repair enzyme activities. In: Mitochondrial DNA: Methods and Protocols, 2nd edition, Ed. J.A. Stuart.  Methods in Molecular Biology Series, J.M. Walker, Human Press, Totowa, New Jersey. June 2009.
  • Robb, E.L., Winkelmolen, L., Visanji, N., Brotchie, J., Stuart, J.A., 2008. Dietary resveratrol administration increases MnSOD expression and activity in mouse brain. Biochem. Biophys. Res. Commun. 372, 254-9.
  • Robb, E.L., Page, M.M., Wiens, B.E. and Stuart, J.A., 2008. A specific, progressive and profound induction of mitochondrial superoxide dismutase in human cells exposed to trans-resveratrol. Biochem. Biophys. Res. Commun. 367, 406-412.
  • Stuart, J.A. and Page, M.M. DNA oxidative damage and cancer. Oxidative Stress in Aging: From Model Systems to Human Diseases. Humana Press, May 2008.
     

 

Dr. Jeffrey Stuart

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