Publications

SELECTED PUBLICATIONS, GROUPED BY TOPIC:
(students are denoted by *)

EARLY LIFE DIET AND PROGRAMMING OF BONE METABOLISM AND REPRODUCTIVE HEALTH

*Dinsdale EC, Chen J, Ward WE. Early life exoosure to isoflavones adversely affects reproductive health in first but not second generation female CD-1 mice. Journal of Nutrition. 141(11):1996-2002, 2011.

*Kaludjerovic J, Ward WE. Neonatal administration of isoflavones attenuates deterioration of bone tissue in female but not male mice. Journal of Nutrition. 140(4):766-772, 2010.

*Kaludjerovic J, Ward WE. Neonatal exposure to daidzein, genistein or the combination modulates bone development in female CD-1 mice. Journal of Nutrition. 139(3):467-473, 2009.


*Kaludjerovic J, Ward WE. Diethylstilbesterol has gender-specific effects on weight gain and bone development in mice. Journal of Toxicology and Environmental Health. 71:1032-1042, 2008.


Ward WE, *Piekarz A. Effect of prenatal exposure to isoflavones on bone metabolism in mice at adulthood. Pediatric Research. 61(4):438-443, 2007.


*Piekarz A, Ward WE. Effect of neonatal exposure to genistein on bone metabolism in mice at adulthood. Pediatric Research. 61(1):48-53, 2007.

FOOD SYNERGY, FOOD-DRUG SYNERGY AND BONE HEALTH

*Sacco SM, Thompson LU, Ward WE. Accesibility of 3H-secoisolariciresinol diglycoside lignan metabolites in skeletal tissue of ovariectomized rats. Journal of Medicinal Food. 14(10)1208-1214, 2011.

*Sacco SM, Jiang JM, Reza-Lopez S, Thompson LU, Ma DWL, Ward WE. Flaxseed does not antagonize the effect of ultra-low dose estrogen therapy on bone mineral density and biomechanical strength in ovariectomized rats. Journal of Toxicology and Environmental Health. 72(20):1209-1216, 2009.


*Sacco SM, *Jiang JM, Reza-Lopez S, Thompson LU, Ma DWL, Ward WE. Flaxseed combined with low dose estrogen therapy preserves in ovariectomized rats. Menopause. 16(3):545-554, 2009.

Ward WE, *Fonseca D. Synergy of soy isoflavones and fish oil: effects on bone tissue post-ovariectomy in mice. Molecular Nutrition and Food Research. 51:824-831, 2007.


EARLY LIFE DIET, INFLAMMATION AND BONE HEALTH

*Cohen SL, Moore AM, Ward WE. Flaxseed oil and inflammation-associated bone abnormalities in interleukin-10 knockout mice. Journal of Nutritional Biochemistry. 16(6):368-374, 2005.

*Cohen SL, Moore AM, Ward WE. Interleukin-10 knockout mouse: a model for studying bone metabolism during intestinal inflammation. Inflammatory Bowel Disease. 10(5):557-563, 2004.

METHODOLOGICAL CONSIDERATIONS WHEN USING RODENT MODELS TO STUDY BONE METABOLISM

*Kaludjerovic J, Franke AA, Ward WE. Circulating isoflavonoid levels in CD-1 mice: effect of oral versus subcutaneous delivery and frequency of administration. Journal of Nutritional Biochemistry. 2011, in press.

*Jiang J, *Sacco SM, Ward WE. Ovariectomy-induced hyperphagia does not modulate bone mineral or bone strength in rats. Journal of Nutrition. 138(11):2106-2110, 2008.

Ward WE, *Piekarz A, Fonseca D. Bone mass, bone strength, and their relationship in developing CD-1 mice. Canadian Journal of Physiology and Pharmacology. 85(2):274-279, 2007.


Ward WE, *Kim S, *Chan D, *Fonseca D. Serum equol, bone mass and biomechanical bone strength differs among four strains of mice. Journal of Nutritional Biochemistry. 16(12):743-749, 2005.

BOOKS


Optimizing Women’s Health Through Nutrition, L.U. Thompson, W.E. Ward (eds), CRC Press, Taylor and Francis Group, Boca Raton, FL. 2007, pp.454


Food-Drug Synergy and Safety, L.U. Thompson, W.E. Ward (eds), CRC Press, Taylor and Francis Group, Boca Raton, FL. 2005. pp. 488.

SELECTED INVITED REVIEWS

*Dinsdale CE, Ward WE. Early exposure to soy isoflavones and effects on reproductive health: a review of human and animal studies. Nutrients. 2(11):1156-1187, 2010.

*Sacco SM, Ward WE. Revisiting estrogen: efficacy and safety of lower doses for postmenopausal bone loss. Journal of Osteoporosis. 2010;708931.

Ward WE, Prevention of bone fragility: the role of diet. International Journal of Clinical Rheumatology. 20(4):30-32, 2009.


SELECTED BOOK CHAPTERS


Ward WE, *Kaludjerovic J, *Lau B, *Sacco SM. In: Functional foods and bone health: where are we at? In: Functional food product development. E. Charter, J. Smith (eds). Wiley-Blackwell, Malden, MA, p. 459-503, 2009

Ward WE. Osteoporosis and osteoarthritis. In: Optimizing women’s health through nutrition. L.U. Thompson, W.E. Ward (eds). CRC Press, Taylor and Francis Group, Boca Raton, FL, p. 265-278, 2007.


Fritz PC and Ward WE. Oral health. In: Optimizing women’s health through nutrition. L.U. Thompson, W.E. Ward (eds). CRC Press, Taylor and Francis Group, Boca Raton, FL, p. 409-421, 2007.


Ward WE. Herbal preparations and nutritional supplements. In. Principles of Medical Pharmacology, 7th Edition. H. Kalant, D. Grant, J. Mitchell (eds). Elsevier Canada, Toronto, Ontario, Canada, p. 868-877, 2007.


Ward WE. Vitamins and other micronutrients. In. Principles of Medical Pharmacology, 7th Edition. H. Kalant, D. Grant, J. Mitchell (eds). Elsevier Canada, Toronto, Ontario, Canada, p. 841-867, 2007.


Ward WE. Synergy of soy, flaxseed, calcium and hormone replacement therapy in osteoporosis. In. Food-Drug Synergy and Safety. L.U. Thompson, W.E. Ward (eds). CRC Press, Taylor and Francis Group, Boca Raton, FL. p. 235-253, 2005.